Polarity-specific high-definition transcranial direct current stimulation of the anterior and posterior default mode network improves remote memory retrieval

BackgroundPrevious studies show that activity in the posterior default mode network (pDMN), including cingulate cortex and precuneus, is correlated with success of long-term episodic memory retrieval. However, role anterior DMN (aDMN) medial prefrontal still unclear. Some activating improves retrieval while other deactivation successful memories, suggesting a possible functional dissociation between aDMN pDMN.ObjectiveIn current study, we aim to causally explore this probable using high-definition transcranial direct stimulation (HD-tDCS).MethodsWe perform randomised double-blinded two-visit placebo-controlled study 84 healthy young adults. During Visit 1 they learn 75 Swahili-English word-associations. Seven days later, randomly receive either anodal, cathodal or sham HD-tDCS targeting pDMN recall what have previously learned.ResultsWe demonstrate anodal aDMN, equally improve percentage word-associations recalled 7 after learning.ConclusionsModulating affect performance. shows increases performance one week learning phase. Given consistent evidence, it highly likely are increasing stimulation. not clear if targetting works via decoupling from indirectly disinhibit pDMN.